RT - Journal Article T1 - The Effect of Alpha-Lipoic Acid on Learning and Memory Deficit in a Rat Model of Temporal Lobe Epilepsy JF - BCN YR - 2012 JO - BCN VO - 3 IS - 3 UR - http://bcn.iums.ac.ir/article-1-236-en.html SP - 58 EP - 66 K1 - Kainic acid K1 - Lipoic acid K1 - Passive avoidance K1 - Y maze K1 - Oxidative stress K1 - Rat AB - Introduction: Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory. Although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. New medications with novel mechanisms of action are needed to help those patients whose seizures are resistant to currently-available drugs. While alpha-lipoic acid as a antioxidant has some neuroprotective properties, but this action has not been investigated in models of epilepsy. Therefore, the protective effect of pretreatment with alpha-lipoic acid was evaluated in experimental model of temporal lobe epilepsy in male rats. Methods: In the present study, Wistar male rats were injected intrahippocampally with 0.9% saline(Sham-operated group), kainic acid(4 μg) alone, or α-lipoic acid (25mg and 50mg/kg) in association with kainic acid(4μg). We performed behavior monitoring(spontaneous seizure, learning and memory by Y-maze and passive avoidance test), intracranial electroencepholography (iEEG) recording, histological analysis, to evaluate the anti- epilepsy effect of α-lipoic acid in kainate-induced epileptic rats. Results: Behavior data showed that the kainate rats exhibit spontaneous seizures, lower spontaneous alternation score inY-maze tasks (p LA eng UL http://bcn.iums.ac.ir/article-1-236-en.html M3 ER -