%0 Journal Article %A Farajdokht, Fereshteh %A Nahavandi, Arezo %A Soleimani, Mansoureh %T Effects of dalteparin on structure of hippocampal neurons of rats in chronic stress %J Basic and Clinical Neuroscience Journal %V 3 %N 3 %U http://bcn.iums.ac.ir/article-1-234-en.html %R %D 2012 %K dalteparin, chronic stress, hippocampus, inflammation, %X Introduction: Stress is defined as any environmental change that disturbs the maintenance of brain homeostasis. Stress leads to production of pro-inflammatory cytokines that provoke neurodegenerative disorders. In the present study, we investigated the effects of dalteparin on hippocampal neuronal death induced by chronic stress in rats. Methods: the study was carried out on 60 adult male wistar rats, weighing 200- 250 gr. The rats were randomly divided into three groups: control, stress and stress + dalteparin (SD) groups. Animals in the stress and stress + dalteparin group were exposed to chronic stress for 4 weeks. Animals in the stress + dalteparin (SD) group received dalteparin (70,100 and 140 IU/kg/days i.p.) during the stress period. After the last stressor animals were sacrificed and concentration of IL-6 in serum was measured using ELISA. All animals were reperfused and their brains were processed for histological analysis through Nissl analysis. Results: We found that the serum concentration of IL-6 was significantly higher in the CMS (Chronic Mild Stress) exposure group than in the control group (p %> http://bcn.iums.ac.ir/article-1-234-en.pdf %P 32-37 %& 32 %! %9 Original %L A-10-1-107 %+ %G eng %@ 2008-126X %[ 2012