@ARTICLE{Nahavandi, author = {Farajdokht, Fereshteh and Nahavandi, Arezo and Soleimani, Mansoureh and }, title = { Effects of dalteparin on structure of hippocampal neurons of rats in chronic stress}, volume = {3}, number = {3}, abstract ={Introduction: Stress is defined as any environmental change that disturbs the maintenance of brain homeostasis. Stress leads to production of pro-inflammatory cytokines that provoke neurodegenerative disorders. In the present study, we investigated the effects of dalteparin on hippocampal neuronal death induced by chronic stress in rats. Methods: the study was carried out on 60 adult male wistar rats, weighing 200- 250 gr. The rats were randomly divided into three groups: control, stress and stress + dalteparin (SD) groups. Animals in the stress and stress + dalteparin group were exposed to chronic stress for 4 weeks. Animals in the stress + dalteparin (SD) group received dalteparin (70,100 and 140 IU/kg/days i.p.) during the stress period. After the last stressor animals were sacrificed and concentration of IL-6 in serum was measured using ELISA. All animals were reperfused and their brains were processed for histological analysis through Nissl analysis. Results: We found that the serum concentration of IL-6 was significantly higher in the CMS (Chronic Mild Stress) exposure group than in the control group (p }, URL = {http://bcn.iums.ac.ir/article-1-234-en.html}, eprint = {http://bcn.iums.ac.ir/article-1-234-en.pdf}, journal = {Basic and Clinical Neuroscience Journal}, doi = {}, year = {2012} }