TY - JOUR JF - BCN JO - BCN VL - 1 IS - 1 PY - 2009 Y1 - 2009/1/01 TI - Neuroprotective effect of quercetin in a model of Parkinson’s disease in rat: A histochemical analysis TT - N2 - AbstractIntroduction: Parkinson's disease (PD) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. Quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. Therefore, its neuroprotective effect in a model of Parkinson’s disease in rat was evaluated.Methods: For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with quercetin (20 mg/kg i.p.) 1 hour before surgery and treated once a day for one month. Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted. Results: Number of Nissl-stained neurons in left side of SNC of lesion group was lower relative to sham-operated group (p SP - 3 EP - 6 AU - Mehdizadeh, Mehdi AU - Taghi Joghataei, Mohammad AU - Nobakht, Maliheh AU - Aryanpour, Roya AD - KW - Quercetin KW - 6-Hydroxydopamine KW - Parkinson’s disease KW - Rat UR - http://bcn.iums.ac.ir/article-1-6-en.html ER -