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1- Kerman University of Medical Sciences, Kerman, Iran.
2- Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
3- Kerman Pharmaceutical Science Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Abstract:  

Purpose of the study: This study was performed to evaluate the effects of Zataria multiflora (ZM) on learning & memory of prenatal lead exposed adult male offspring rats .

Methods: Pregnant rats in case group received tap water containing 0.2 % lead acetate throughout the gestation period. Control rats had free access to tap water. Two male offspring from each mother (2months old, weighing 180-200g) were randomly selected and were treated with either Zataria multiflora (50, 200, 400 & 800mg/kg/ i.p./20 d) or saline. Spatial memory of control, saline and ZM-treated rats was evaluated by a training trial and probe test using Morris water maze (6-8 rat/group).

Results: The data showed increased escape latency and a greater travelled distance as well as decrements in the frequency of crossings into target quadrants in antenatally lead exposed male offspring compared to control. ZM treatment (200mg/kg/i.p) ameliorate the memory deficits in male offspring by increasing the time spent and travelled distance in the trigger zone (P<0.01 vs saline).There was no significant difference in swimming speed between groups.

 Conclusion: The results showed memory deficits in antenatally lead exposed male offspring. ZM treatment (especially 200 mg/kg) showed the beneficial effects on cognitive behavior in prenatally lead exposed male rats. The exact mechanism(s) is not determined yet, but it could be mediated through the anticholinesterase and antioxidant effects and also alterations in CNS neurotransmission in the central nervous system.

Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2017/03/13 | Accepted: 2017/08/29

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