دوره 9، شماره 6 - ( Issue in Progress 1397 )                   جلد 9 شماره 6 صفحات 429-438 | برگشت به فهرست نسخه ها


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Ahmadi L, Kazemi Nezhad S R, Behbahani P, Khajeddin N, Pourmehdi-Boroujeni M. Genetic Variations of DAOA (rs947267 and rs3918342) and COMT Genes (rs165599 and rs4680) in Schizophrenia and Bipolar I Disorder. BCN. 2018; 9 (6) :429-438
URL: http://bcn.iums.ac.ir/article-1-908-fa.html
Genetic Variations of DAOA (rs947267 and rs3918342) and COMT Genes (rs165599 and rs4680) in Schizophrenia and Bipolar I Disorder. مجله علوم اعصاب پایه و بالینی. 1397; 9 (6) :429-438

URL: http://bcn.iums.ac.ir/article-1-908-fa.html


چکیده:  
Introduction: Genetic and environmental factors are involved in the incidence of schizophrenia and bipolar disorder. Many reports confirm that several common genes are connected with these two psychotic disorders. Several neurotransmitters may be involved in the molecular mechanisms of schizophrenia and bipolar disorder. We aimed to estimate the role of two talent genes: DAOA in neurotransmission of glutamate and COMT in neurotransmission of dopamine to guide the treatment of schizophrenia and bipolar disorder. 
Methods: Blood samples (n=100 for schizophrenia, n=100 for bipolar I disorder and n=127 for case control) were collected from individuals unrelated in the southwest of Iran. The SNPs (rs947267 and rs3918342 for DAOA gene/ rs165599 and rs4680 for COMT gene) were genotyped using the PCR-RFLP method. Our finding was studied by logistic regression and Mantel-Haenszel Chi-square tests.
Results: We observed an association in rs3918342, rs165599 and rs4680 single nucleotide polymorphisms and schizophrenia and bipolar I disorder. In addition, our data demonstrated that the rs947267 was related to bipolar I disorder but there was no association between this SNP and schizophrenia.
Conclusion: In conclusion, this result supports the hypothesis that variations in DAOA and COMT genes may play a role in schizophrenia and bipolar disorder.
نوع مطالعه: Original | موضوع مقاله: Cellular and molecular Neuroscience
دریافت: ۱۳۹۵/۱۱/۱۳ | پذیرش: ۱۳۹۷/۳/۵ | انتشار: ۱۳۹۷/۸/۱۰

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