Volume 9, Issue 1 (January & February 2018 2018)                   BCN 2018, 9(1): 59-64 | Back to browse issues page

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Vahedi M, Mazdeh M, Hajilooi M, Farhadian M, Barakian Y, Sadr P. The Relationship Between Salivary Alpha Amylase Activity and Score of McGill Pain Questionnaire in Patients With Tension Type Headache. BCN. 2018; 9 (1) :59-64
URL: http://bcn.iums.ac.ir/article-1-907-en.html
1- Department of Oral Medicine, School of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran.
2- Department of Neurology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
3- Department of Immunology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
4- Research Center for Health Sciences, Hamedan University of Medical Sciences, Hamedan, Iran.
5- Department of Oral Medicine, Faculty of Dentistry, Qom University of Medical Science and Health Services, Qom, Iran.
6- Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.

Introduction: Tension-type headache is the most common type of headache across the world. Saliva as a non-invasive medium is used to detect a wide range of diseases. Salivary Alpha-Amylase (SAA) levels has been suggested as a potential indirect marker for detecting Sympathoadrenal Medullary (SAM) activity, which is activated by pain. Significant correlation was found between SAA levels and pain scale in patients with chronic pain. The purpose of the present study was to measure SAA activity in Frequent Episodic Tension-Type Headache (FETTH). In addition to the Visual Analogue Scale (VAS), we intend to assess intensity and various aspects of pain by McGill Pain Questionnaire (MPQ). 
Methods:  A total of 45 females with FETTH (case group) and 45 healthy voluntary females (control group) were enrolled in our case-control study. Unstimulated saliva by spitting method was taken from each participant. 
Results: SAA levels were significantly higher in patients with FETTH (P<0.001) when compared with the control group. There was significant correlation between SAA activity and MPQ score (P<0.001).
Conclusion: This is the first study using MPQ as a subjective means of assessing quality and quantity of pain alongside the VAS as an objective tool for evaluating pain in patients with FETTH. SAA may be an appropriate marker for assessing of pain levels in patients with FETTH. MPQ versus the VAS may be a more accurate measurement tools along VAS.

Type of Study: Original | Subject: Clinical Neuroscience
Received: 2017/01/31 | Accepted: 2017/04/30 | Published: 2018/01/1

1. Ahmadi- Motamayel, F., Goodarzi, M. T., Jamshidi, Z., Mahdavinezhad, A., & Rafieian, N. (2016). Evaluation of salivary and serum alpha amylase level in dental caries of adolescence. Brazilian Dental Science, 19(2), 40-6. doi: 10.14295/bds.2016.v19i2.1227 [DOI:10.14295/bds.2016.v19i2.1227]
2. Ahmadi-Motamayel, F., Shahriari, S., Goodarzi, M. T., Moghimbeigi, A., Jazaeri, M., & Babaei, P. (2013). The relationship between the level of salivary alpha amylase activity and pain severity in patients with symptomatic irreversible pulpitis. Restorative Dentistry & Endodontics, 38(3), 141-45. doi: 10.5395/rde.2013.38.3.141 [DOI:10.5395/rde.2013.38.3.141]
3. Bugdayci, G., Yildiz, S., Altunrende, B., Yildiz, N., & Alkoy, S. (2010). Salivary alpha amylase activity in migraine patients. Autonomic Neuroscience, 155(1-2), 121–124. doi: 10.1016/j.autneu.2010.01.011 [DOI:10.1016/j.autneu.2010.01.011]
4. Burckhardt, C. S., & Jones, K. D. (2003). Adult measures of pain: The McGill Pain Questionnaire (MPQ), Rheumatoid Arthritis Pain Scale (RAPS), Short-Form McGill Pain Questionnaire (SF-MPQ), Verbal Descriptive Scale (VDS), Visual Analog Scale (VAS), and West Haven-Yale Multidisciplinary Pain Inventory (WHYMPI). Arthritis & Rheumatism, 49(S5), S96–S104. doi: 10.1002/art.11440 [DOI:10.1002/art.11440]
5. Cathcart, S., Winefield, A. H., Lushington, K., & Rolan, P. (2010). Stress and tension-type headache mechanisms. Cephalalgia, 30(10), 1250–1267. doi: 10.1177/0333102410362927 [DOI:10.1177/0333102410362927]
6. Crystal, S. C., & Robbins, M. S. (2010). Epidemiology of tension-type headache. Current Pain and Headache Reports, 14(6), 449–454. doi: 10.1007/s11916-010-0146-2 [DOI:10.1007/s11916-010-0146-2]
7. Faulkner, W., & Meites, S. (1982). Selected methods for the small clinical chemistry laboratory, Vol. 9 .Washington: American Association for Clinical Chemistry.
8. Headache Classification Committee of the International Headache Society. (2013). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia, 33(9), 629-808. doi: 10.1177/0333102413485658 [DOI:10.1177/0333102413485658]
9. Holroyd, K. A., Holm, J. E., Keefe, F. J., Turner, J. A., Bradley, L. A., Murphy, W. D., et al. (1992). A multi-center evaluation of the McGill Pain Questionnaire: Results from more than 1700 chronic pain patients. Pain, 48(3), 301–11. doi: 10.1016/0304-3959(92)90077-o [DOI:10.1016/0304-3959(92)90077-O]
10. Khosravi, M., Sadighi, S., Moradi, S., & Zendehdel, K. (2013). [Persian-McGill pain questionnaire translation, adaptation and reliability in cancer patients: A brief report (Persian)]. Tehran University Medical Journal, 71(1), 53-58.
11. Tripathi, L., & Kumar, P. (2014). Challenges in pain assessment: Pain intensity scales. Indian Journal of Pain, 28(2), 61-70. doi: 10.4103/0970-5333.132841 [DOI:10.4103/0970-5333.132841]
12. Majani, G., Tiengo, M., Giardini, A., Calori, G., De Micheli, P., & Battaglia, A. (2003). Relationship between MPQ and VAS in 962 Patients: A Rationale for Their Use. Minerva Anestesiologica. 69(1-2), 67-73. PMID: 12677163 [PMID]
13. Melzack, R. (1975). The McGill Pain Questionnaire: Major properties and scoring methods. Pain, 1(3), 277–99. doi: 10.1016/0304-3959(75)90044-5 [DOI:10.1016/0304-3959(75)90044-5]
14. Nater, U. M., & Rohleder, N. (2009). Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: Current state of research. Psychoneuroendocrinology, 34(4), 486–96. doi: 10.1016/j.psyneuen.2009.01.014 [DOI:10.1016/j.psyneuen.2009.01.014]
15. Ngamkham, S., Vincent, C., Finnegan, L., Holden, J. E., Wang, Z. J., & Wilkie, D. J. (2012). The McGill Pain Questionnaire as a Multidimensional Measure in People with Cancer: An Integrative Review. Pain Management Nursing, 13(1), 27–51. doi: 10.1016/j.pmn.2010.12.003 [DOI:10.1016/j.pmn.2010.12.003]
16. Noto, Y., Sato, T., Kudo, M., Kurata, K., & Hirota, K. (2005). The relationship between salivary biomarkers and state-trait anxiety inventory score under mental arithmetic stress: A pilot study. Anesthesia & Analgesia, 101, 1873-76. doi: 10.1213/01.ane.0000184196.60838.8d [DOI:10.1213/01.ANE.0000184196.60838.8D]
17. Rantonen, P. (2003). Salivary flow and composition in the healthy and diseased adult [PhD dissertation]. Helsinki: University of Helsinki.
18. Rohleder, N., Wolf, J. M., Maldonado, E. F., & Kirschbaum, C. (2006). The psychosocial stress-induced increase in salivary alpha-amylase is independent of saliva flow rate. Psychophysiology, 43(6), 645–52. doi: 10.1111/j.1469-8986.2006.00457.x [DOI:10.1111/j.1469-8986.2006.00457.x]
19. Shirasaki, S., Fujii, H., Takahashi, M., Sato, T., Ebina, M., Noto, Y., et al. (2007). Correlation between salivary α-amylase activity and pain scale in patients with chronic pain. Regional Anesthesia and Pain Medicine, 32(2), 120–123. doi: 10.1016/j.rapm.2006.11.008 [DOI:10.1016/j.rapm.2006.11.008]
20. Tandon, M., Singh, A., Saluja, V., Dhankhar, M., Pandey, C. K., & Jain, P. (2016). Validation of a New "Objective Pain Score" Vs. "Numeric Rating Scale" For the Evaluation of Acute Pain: A Comparative Study. Anesthesiology and Pain Medicine, 6(1), e32101. doi:10.5812/aapm.32101 [DOI:10.5812/aapm.32101]
21. Tsuchiya, K., Saidin, M. Y. B., Inoue, T., Kajiwara, K., & Kimura, M. (2014). Qualitative measurement of pain by analysing the salivary alpha amylase. Precision Engineering, 38(2), 257–60. doi:10.1016/j.precisioneng.2013.09.006 [DOI:10.1016/j.precisioneng.2013.09.006]
22. Van Stegeren, A., Rohleder, N., Everaerd, W., & Wolf, O. T. (2006). Salivary alpha amylase as marker for adrenergic activity during stress: effect of betablockade. Psychoneuroendocrinology, 31(1), 137–141. doi: 10.1016/j.psyneuen.2005.05.012 [DOI:10.1016/j.psyneuen.2005.05.012]
23. Wilkie, D., Savedra, M., Holzemer, W., Tesler, M., & Paul, S. (1990). Use of the McGill Pain Questionnaire to measure pain: a meta-analysis. Nursing Research, 39(1), 36–41. doi: 10.1097/00006199-199001000-00008 [DOI:10.1097/00006199-199001000-00008]

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