Volume 9, Issue 5 (September & October 2018 2018)                   BCN 2018, 9(5): 0-0 | Back to browse issues page

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Khosravi A, Dianatkhah M, Noori F, Sarrafzadegan N, Nejati M, Behjati M. Which side of paternal and maternal history of cerebrovascular diseases enhances more its risk in offspring in a cohort of Iranian population?. BCN. 2018; 9 (5)
URL: http://bcn.iums.ac.ir/article-1-878-en.html
1- Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
3- Isfahan Cardiovascular Research Center (WHO Collaborating Center in the EMR), Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
4- Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.
5- Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Introduction: still a controversial issue, family history is known as a risk factor for the development of Cerebrovascular Diseases (CVD). In this study, we aimed to evaluate the relationship between parental history and risk of CVD in their offspring in Iranian population. 
Methods: Isfahan Cohort Study (ICS) included total 6504 healthy participants which were randomly selected through a two-stage cluster sampling method from three districts. The participants were followed prospectively for 10 years. The patients with CVD were diagnosed by a neurologist. Clinically validated history of CVD was established for definition of parental history of CVD. Types of history were categorized into paternal, maternal, both parents, and no history.
Results: The prevalence of CVD is generally higher among female offspring compared with male ones (P<0.001). The relative risk of CVD with maternal history was not significant (95%CI= 0.95-2.29). By adjusted model analysis, history of CVD in both parents affected the risk of CVD in their male children (RR=2.13, P=0.033, 95%CI). By crude model analysis, maternal history of CVD (P=0.047), history of CVD in both parents (P=0.032), and maternal history of hypertension (P=0.005) were determined as risk factors of CVD in offspring. Indeed, the mean age of CVD in offspring decreases based on this order: history of hypertension in parents, paternal history of CVD in both parents, maternal history of CVD, and no history (P<0.001). 
Conclusion: Early and regular screening for CVD development is necessary in female offspring of the families with the present history of CVD from maternal side. This group are at risk and should be considered as the target group for screening and taking preventive measures

Type of Study: Original | Subject: Clinical Neuroscience
Received: 2016/12/7 | Accepted: 2017/12/18 | Published: 2018/09/1

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