Volume 7, Issue 4 (Autumn 2016 -- 2016)                   BCN 2016, 7(4): 283-290 | Back to browse issues page

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Arash Motahari A, Sahraei H, Meftahi G H. Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency. BCN. 2016; 7 (4) :283-290
URL: http://bcn.iums.ac.ir/article-1-832-en.html
1- Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

The catastrophic effects of opioids use on public health and the economy are documented clearly in numerous studies. Repeated morphine administration can lead to either a decrease (tolerance) or an increase (sensitization) in its behavioral and rewarding effects. Morphine-induced sensitization is a major problem and plays an important role in abuse of the opioid drugs. Studies reported that morphine may exert its effects by the release of nitric oxide (NO). NO is a potent neuromodulator, which is produced by nitric oxide synthase (NOS). However, the exact role of NO in the opioid-induced sensitization is unknown. In this study, we reviewed the role of NO on opioid-induced sensitization in 2 important, rewarding regions of the brain: nucleus accumbens and ventral tegmentum. In addition, we focused on the contribution of NO on opioid-induced sensitization in the limbic system.

Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2016/04/7 | Accepted: 2016/09/1 | Published: 2016/10/1

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