دوره 7، شماره 4 - ( Autumn 2016 -- 1395 )                   جلد 7 شماره 4 صفحات 283-290 | برگشت به فهرست نسخه ها




DOI: 10.15412/J.BCN.03070401
PMCID: 16362626

Cited 0 times in PubMed Central

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Arash Motahari A, Sahraei H, Meftahi G H. Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency. BCN. 2016; 7 (4) :283-290
URL: http://bcn.iums.ac.ir/article-1-832-fa.html
Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency. مجله علوم اعصاب پایه و بالینی. 1395; 7 (4) :283-290

URL: http://bcn.iums.ac.ir/article-1-832-fa.html


چکیده:  

The catastrophic effects of opioids use on public health and the economy are documented clearly in numerous studies. Repeated morphine administration can lead to either a decrease (tolerance) or an increase (sensitization) in its behavioral and rewarding effects. Morphine-induced sensitization is a major problem and plays an important role in abuse of the opioid drugs. Studies reported that morphine may exert its effects by the release of nitric oxide (NO). NO is a potent neuromodulator, which is produced by nitric oxide synthase (NOS). However, the exact role of NO in the opioid-induced sensitization is unknown. In this study, we reviewed the role of NO on opioid-induced sensitization in 2 important, rewarding regions of the brain: nucleus accumbens and ventral tegmentum. In addition, we focused on the contribution of NO on opioid-induced sensitization in the limbic system.

نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۵/۱/۱۹ | پذیرش: ۱۳۹۵/۶/۱۱ | انتشار: ۱۳۹۵/۷/۱۰

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