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Shahmiri E, Jafari Z, Noroozian M, Zendehbad A, Haddadzadeh Niri H, Yoonessi A. Effect of Mild Cognitive Impairment and Alzheimer Disease on Auditory Steady-State Responses. BCN. 2017;
URL: http://bcn.iums.ac.ir/article-1-797-en.html

1- 1Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2- Department of Basic Sciences, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
4- Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
5- MD, PhD Research Center for Cognitive and Behavioral Sciences ??, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Mild cognitive impairment (MCI), a disorder of the elderly people, is difficult to diagnose and often progresses to Alzheimer disease (AD). Temporal region is one of the initial areas, which gets imapaired in the early stage of AD. Therefore, auditory cortical evoked potential could be a valuable neuromarker for detecting MCI and AD.

Methods: In this study, the thresholds of auditory steady state response (ASSR) to 40 Hz and 80 Hz were compared between Alzheimer (AD), MCI, and control groups. A total of 42 patients (12 with AD, 15 with MCI, and 15 elderly normal controls) were tested for ASSR. Hearing thresholds at 500, 1000, and 2000 Hz in both ears with modulation rates at 40 and 80 Hz were obtained.

Results: Significant differences in normal subjects were observered in estimated ASSR thresholds with two modulation rates in 3 frequencies in both ears. However, the difference was significant only in 500 Hz in the MCI group, and no significant differences were observed in the AD group. In addition, significant differences were observed between the normal subjects and AD patients with regard to the estimated ASSR thresholds with 2 modulation rates 3 frequencies in both ears. A significant difference was observed between the normal and MCI groups at 2000 Hz. An increase in estimated 40 Hz ASSR thresholds in Alzheimer and MCI patients suggests neural changes in auditory cortex compared to that in normal ageing.

Conclusion: Auditory threshold estimation with low and high modulation rates by ASSR test could be a potentially helpful test for detecting cognitive impairment.

Type of Study: Original | Subject: Cognitive Neuroscience
Received: 2016/06/23 | Accepted: 2016/08/10 | Published: 2017/02/23

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