دوره 8، شماره 3 - ( May & June 2017 -- 1396 )                   جلد 8 شماره 3 صفحات 213-222 | برگشت به فهرست نسخه ها


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Kooshki R, Abbasnejad M, Esmaeili-Mahani S, Raoof M. Research Paper: The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats. BCN. 2017; 8 (3) :213-222
URL: http://bcn.iums.ac.ir/article-1-751-fa.html
Research Paper: The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats. مجله علوم اعصاب پایه و بالینی. 1396; 8 (3) :213-222

URL: http://bcn.iums.ac.ir/article-1-751-fa.html


چکیده:  

Introduction: Cognitive impairment is commonly associated with pain. The modulatory role of orexin 1 receptor (OX1R) in pain pathways as well as learning and memory processes is reported in several studies. The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain.
Methods: Orofacial pain was induced by subcutaneous intra lip injection of capsaicin (100 μg). CA1 administration of orexin A and its selective antagonist (SB-334867-A) were performed 20 minutes prior to capsaicin injection. Learning and spatial memory performances were assessed by Morris Water Maze (MWM) task.
Results: Capsaicin treated rats showed impairment in spatial learning and memory. In addition, pretreatment with orexin A (20 and 40 nM/rat) significantly attenuated learning and memory impairment in capsaicin-treated rats. Conversely, blockage of OX1R via SB-334867-A (40 and 80 nM/rat) significantly exaggerated learning and memory loss in capsaicin-treated rats. 
Conclusion: The obtained results indicated that CA1 OX1R may be involved in modulation of capsaicin –induced spatial learning and memory impairment.

نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۵/۷/۲۳ | پذیرش: ۱۳۹۵/۱۱/۵ | انتشار: ۱۳۹۶/۲/۱۱

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