Volume 7, Issue 3 (Summer 2016 -- 2016)                   BCN 2016, 7(3): 259-268 | Back to browse issues page

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Raoof M, Ebrahimnejad H, Abbasnejad M, Amirkhosravi L, Raoof R, Esmaeili Mahani S, et al . The Effects of Inflammatory Tooth Pain on Anxiety in Adult Male Rats. BCN. 2016; 7 (3) :259-268
URL: http://bcn.iums.ac.ir/article-1-641-en.html
1- Oral and Dental Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran.
2- Department of Oral & Maxillofacial Radiology, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
4- Laboratory of Molecular Neuroscience, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
5- Department of Endodontics, Faculty of Dentistry, Mazandaran University of Medical Sciences, Mazandaran, Iran.
6- Dental Research Center, Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: This study aimed to examine the effects of induced inflammatory tooth pain on anxiety level in adult male rats.
Methods: The mandibular incisors of 56 adult male rats were cut off and prefabricated crowns were fixed on the teeth. Formalin and capsaicin were injected intradentally to induce inflammatory tooth pain. Diazepam treated group received diazepam 30 minutes before intradental injection. The anxietyrelated behavior was evaluated with elevated plus maze test.
Results: Intradental application of chemical noxious stimuli, capsaicin and formalin, significantly affected nociceptive behaviors (P<0.001). Capsaicin (P<0.001) and formalin (P<0.01) significantly increased the anxiety levels in rats by decrease in the duration of time spent in open arm and increase in the duration of time spent in closed arm. Rats that received capsaicin made fewer open arm entries compared to the control animals (P<0.05). Capsaicin (P<0.001) and formalin (P<0.01) treated rats showed more stretch attend postures compared to the control and sham operated animals. In diazepampretreated
rats, capsaicin induced algesic effect was prevented (P<0.001).
Conclusion: Inflammatory pulpal pain has anxiogenic effect on rats, whereas diazepam premedication showed both anxiolytic and pain reducing effects.

Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2015/06/8 | Accepted: 2015/10/15 | Published: 2016/07/1

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