دوره 7، شماره 3 - ( Summer 2016 -- 1395 )                   جلد 7 شماره 3 صفحات 259-268 | برگشت به فهرست نسخه ها




DOI: 10.15412/J.BCN.03070311
PMID: 27563419
PMCID: PMC4981838

Cited 1 time in PubMed Central

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Raoof M, Ebrahimnejad H, Abbasnejad M, Amirkhosravi L, Raoof R, Esmaeili Mahani S, et al . The Effects of Inflammatory Tooth Pain on Anxiety in Adult Male Rats. BCN. 2016; 7 (3) :259-268
URL: http://bcn.iums.ac.ir/article-1-641-fa.html
The Effects of Inflammatory Tooth Pain on Anxiety in Adult Male Rats. مجله علوم اعصاب پایه و بالینی. 1395; 7 (3) :259-268

URL: http://bcn.iums.ac.ir/article-1-641-fa.html


چکیده:  

Introduction: This study aimed to examine the effects of induced inflammatory tooth pain on anxiety level in adult male rats.
Methods: The mandibular incisors of 56 adult male rats were cut off and prefabricated crowns were fixed on the teeth. Formalin and capsaicin were injected intradentally to induce inflammatory tooth pain. Diazepam treated group received diazepam 30 minutes before intradental injection. The anxietyrelated behavior was evaluated with elevated plus maze test.
Results: Intradental application of chemical noxious stimuli, capsaicin and formalin, significantly affected nociceptive behaviors (P<0.001). Capsaicin (P<0.001) and formalin (P<0.01) significantly increased the anxiety levels in rats by decrease in the duration of time spent in open arm and increase in the duration of time spent in closed arm. Rats that received capsaicin made fewer open arm entries compared to the control animals (P<0.05). Capsaicin (P<0.001) and formalin (P<0.01) treated rats showed more stretch attend postures compared to the control and sham operated animals. In diazepampretreated
rats, capsaicin induced algesic effect was prevented (P<0.001).
Conclusion: Inflammatory pulpal pain has anxiogenic effect on rats, whereas diazepam premedication showed both anxiolytic and pain reducing effects.

نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۴/۳/۱۸ | پذیرش: ۱۳۹۴/۷/۲۳ | انتشار: ۱۳۹۵/۴/۱۱

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