دوره 8، شماره 2 - ( March & April 2017 -- 1395 )                   جلد 8 شماره 2 صفحات 128-121 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ranjbaran M, Aghaei H, Hajihoseinlou V, Sahraei H, Ranjbaran K. Transient Inactivation of Shell Part of Nucleus Accumbens Inhibits and Exacerbates Stress-Induced Metabolic Alterations in Wistar Rats . BCN 2017; 8 (2) :121-128
URL: http://bcn.iums.ac.ir/article-1-639-fa.html
Transient Inactivation of Shell Part of Nucleus Accumbens Inhibits and Exacerbates Stress-Induced Metabolic Alterations in Wistar Rats . مجله علوم اعصاب پایه و بالینی. 1395; 8 (2) :121-128

URL: http://bcn.iums.ac.ir/article-1-639-fa.html


چکیده:  

Introduction: The role of different parts of the extended amygdala in metabolic signs of stress is not well understood. In the present study, we decided to evaluate the impact of the shell part of nucleus accumbens (NAc) on metabolic disturbance induced by electro foot shock stress using transient inactivation method in the rat. 
Methods: Male Wistar rats (W: 230-250 g) were canuulated unilaterally in the shell part of nucleus accumbens and left one week for recovery. Five minutes before each stress session, the animals either received sterile saline (0.25 µl/side) (control) or lidocaine 2% (0.25 µl/side) (experiment). Blood samples were taken from rats’ retro-orbital sinus for plasma corticosterone measurements. In addition, animals’ weight gain, food and water intake, locomotor activity, and rearing were recorded. 
Results: Stress reduced weight gain and food intake, increased water intake and plasma corticosterone level, and reduces locomotor activity and rearing. Transient inactivation of the right side of the NAc inhibits the stress effect on weight gain, water intake and plasma corticosterone level, but not food intake. However, when the left side of the NAc was inactivated, only weight gain was affected and other parameters were not differing from stress group. Even thought, the plasma corticosterone level was elevated. 
Conclusion: In conclusion, our data indicated that right side of shell part of NAc transient inactivation leads to reduction in metabolic signs of stress but left side of shell part of the NAc inactivation even exacerbates stress signs.

نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: 1395/7/8 | پذیرش: 1395/10/9 | انتشار: 1395/12/11

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Basic and Clinical Neuroscience می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb