Volume 6, Issue 2 (Spring 2015 -- 2015)                   BCN 2015, 6(2): 73-82 | Back to browse issues page

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Khakpour-Taleghani B, Reisi Z, Haghparast A. The Blockade of D1/D2-Like Dopamine Receptors within the Dentate Gyrus of Hippocampus Decreased the Reinstatement of Morphine-Extinguished Conditioned Place Preference in Rats. BCN. 2015; 6 (2) :73-82
URL: http://bcn.iums.ac.ir/article-1-612-en.html
1- Cellular & Molecular Research Center and Department of Physiology, School of ‎Medicine, Guilan University of Medical Sciences, Rasht, Iran
2- Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, ‎P.O.Box 19615-1178, Tehran, Iran
Introduction: The hippocampus (HIP), the primary brain structure related to learning and memory, receives sparse but comprehensive dopamine innervations and contains dopamine D1/D2-like receptors. It is demonstrated that dopamine receptors in dentate gyrus (DG) region of HIP have a remarkable function in spatial reward processing. Much less is known about the involvement of HIP and its D1/D2 dopamine receptors in drug-seeking behaviors, more particularly, in the morphine extinguished conditioned place preference (CPP). 
Methods: To find out the role of D1/D2-like receptors within the DG in morphine-seeking behaviors, forty adult male albino Wistar rats weighing 220-280g were unilaterally implanted by a cannula into the DG. The CPP paradigm was done conditioning score and locomotors activity were recorded by Ethovision software. All drugs/vehicles were microinjected one day after extinction (just before the CPP test) into the DG as reinstatement day. 
Results: The results showed that intra-DG administration of different dose of SCH23390 (0.25, 1 and 4μg/0.5μl saline), as a selective D1-like receptor antagonist and sulpiride (0.25, 1 and 4μg/0.5μl DMSO), as a selective D2-like receptor antagonist dose-dependently attenuated the morphine-extinguished CPP reinstated by priming injection of morphine (1 mg/kg, sc). 
Discussion: It can be concluded that D1/D2-like receptors within this region have an important role in morphine-seeking behaviors in extinguished rats.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2014/08/6 | Accepted: 2015/02/18 | Published: 2015/04/1

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