Volume 6, Issue 4 (Automn 2015 -- 2015)                   BCN 2015, 6(4): 285-290 | Back to browse issues page

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1- Associate professor of physiology, Department of Physiology, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.
2- Local Studies & Specialty Services of Jahad-e-Daneshgahi, Sistan and Baluchistan Branch, Zahedan, Iran.
3- surgical unit, Emam Ali Hospital
Introduction: Borago officinalis flower (borage) is a known sedative in herbal medicine the aim of the present study was to evaluate the antinociceptive effect of borage hydroalcoholic extract in formalin test male rats. 
Methods: Fifty-six adult male albino Wistar rats were randomly divided into seven groups: Control groups of A (intact), B (saline), and C (Positive control) plus test groups of D, E, F, and G (n=8). The groups D, E , and F received 6.25, 12.5, and 25 mg/kg, Borago officinalis flower hydroalcholic extract before the test, respectively but group G received 25 mg/kg borage extract and aspirin before the test. A biphasic pain was induced by injection of formalin 1%. The obtained data were analyzed by SPSS software ver. 17 employing statistical tests of Kruskal- Wallis and Mann-Whitney. The results were expressed as mean±SD. Statistical differences were considered significant at P<0.05. 
Results: The results revealed that the acute and chronic pain behavior score in test groups of D, E, F, and G significantly decreased compared to groups A and B, but this score did not show any difference compared to group C. Moreover, chronic pain behavior score in group G was significantly lower than all other groups. 
Discussion: The results indicated that Borago officinalis hydroalcoholic extract affects the acute and chronic pain behavior response in formaline test male rats.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2015/02/12 | Accepted: 2015/07/7 | Published: 2015/10/1