دوره 7، شماره 2 - ( Spring 2016 -- 1395 )                   جلد 7 شماره 2 صفحات 97-106 | برگشت به فهرست نسخه ها




DOI: 10.15412/J.BCN.03070203
PMID: 27303604
PMCID: PMC4892325

Cited 2 times in PubMed Central

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Hajipour S, Sarkaki A, Farbood Y, Eidi A, Mortazavi P, Valizadeh Z. Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies. BCN. 2016; 7 (2) :97-106
URL: http://bcn.iums.ac.ir/article-1-579-fa.html
Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies. مجله علوم اعصاب پایه و بالینی. 1395; 7 (2) :97-106

URL: http://bcn.iums.ac.ir/article-1-579-fa.html


چکیده:  

Introduction: To study the effect of gallic acid (GA) on hippocampal long-term potentiation (LTP) and histological changes in animal model of Alzheimer disease (AD) induced by betaamyloid (Aβ).
Methods: Sixty-four adult male Wistar rats (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4-7) AD+GA (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) Cont+GA100, Aβ (1μg/μL in each site) was infused into hippocampus bilaterally. Changes of amplitude and slope of LTP induced in hippocampal dentate gyrus (DG) were evaluated by high frequency stimulation (HFS) of perforant path (PP).
Results: Data showed that LTP amplitude and area under curve significantly impaired in AD rats (P<0.001), while significantly improved in AD rats treated with GA (P<0.05, P<0.01).
Conclusion: Current findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of A&beta; but with no effect on healthy rats.

نوع مطالعه: Original | موضوع مقاله: Cognitive Neuroscience
دریافت: ۱۳۹۴/۲/۴ | پذیرش: ۱۳۹۴/۶/۱۰ | انتشار: ۱۳۹۵/۱/۱۳

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