دوره 7، شماره 2 - ( Spring 2016 -- 1395 )                   جلد 7 شماره 2 صفحات 115-120 | برگشت به فهرست نسخه ها




DOI: 10.15412/J.BCN.03070205
PMID: 27303606
PMCID: PMC4892316

Cited 2 times in PubMed Central

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Eftekhari S, Mehrabi S, Karimzadeh F, Joghataei M, Khaksarian M, Hadjighassem M R, et al . Brain Derived Neurotrophic Factor Modification of Epileptiform Burst Discharges in a Temporal Lobe Epilepsy Model. BCN. 2016; 7 (2) :115-120
URL: http://bcn.iums.ac.ir/article-1-529-fa.html
Brain Derived Neurotrophic Factor Modification of Epileptiform Burst Discharges in a Temporal Lobe Epilepsy Model. مجله علوم اعصاب پایه و بالینی. 1395; 7 (2) :115-120

URL: http://bcn.iums.ac.ir/article-1-529-fa.html


چکیده:  

Introduction: Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-β1 gene polymorphism has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide a relatively comprehensive account of the relation between -509C/T gene polymorphisms of TGF-β1 and susceptibility to IS.
Methods: Male Wistar rats were divided into sham (receiving phosphate buffered saline within dorsal hippocampus), pilocarpine (epileptic model of TLE), single injection BDNF (epileptic rats which received single high dose of BDBF within dorsal hippocampus), and multiple injections BDNF (epileptic rats which received BDNF in days 10, 11, 12, and 13 after induction of TLE) groups. Their electrocorticogram was recorded and amplitude, frequency, and duration of spikes were evaluated.
Results: Amplitude and frequency of epileptiform burst discharges were significantly decreased in animals treated with BDNF compared to pilocarpine group.
Conclusion: Our findings suggested that BDNF may modulate the epileptic activity in the animal model of TLE. In addition, it may have therapeutic effect for epilepsy. More studies are
necessary to clarify the exact mechanisms of BDNF effects.

نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۴/۱/۸ | پذیرش: ۱۳۹۴/۴/۲۷ | انتشار: ۱۳۹۴/۱/۱۲

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