دوره 5، شماره 3 - ( Summer 2014 1393 )                   جلد 5 شماره 3 صفحات 231-239 | برگشت به فهرست نسخه ها



PMID: 25337385
PMCID: PMC4202546

Cited 3 times in PubMed Central

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Taherian F, Vafaei A A, Vaezi G H, Eskandarian S, Kashefi A, Rashidy-Pour A. Propranolol–induced Impairment of Contextual Fear Memory Reconsolidation in Rats: A Similar Effect on Weak and Strong Recent and Remote Memories. BCN. 2014; 5 (3) :231-239
URL: http://bcn.iums.ac.ir/article-1-516-fa.html
Propranolol–induced Impairment of Contextual Fear Memory Reconsolidation in Rats: A similar Effect on Weak and Strong Recent and Remote Memories. مجله علوم اعصاب پایه و بالینی. 1393; 5 (3) :231-239

URL: http://bcn.iums.ac.ir/article-1-516-fa.html


چکیده:  

Introduction: Previous studies have demonstrated that the &beta-adrenergic receptor antagonist propranolol impairs fear memory reconsolidation in experimental animals. There are experimental parameters such as the age and the strength of memory that can interact with pharmacological manipulations of memory reconsolidation. In this study, we investigated the ability of the age and the strength of memory to influence the disrupting effects of propranolol on fear memory reconsolidation in rats.

Methods: The rats were trained in a contextual fear conditioning using two (weak training) or five (strong training) footshocks (1mA). Propranolol (10mg/kg) injection was immediately followed retrieval of either a one-day recent (weak or strong) or 36-day remote (weak or strong) contextual fear memories.

Results: We found that propranolol induced a long-lasting impairment of subsequent expression of recent and remote memories with either weak or strong strength. We also found no memory recovery after a weak reminder shock. Furthermore, no significant differences were found on the amount of memory deficit induced by propranolol among memories with different age and strength.

Discussion: Our data suggest that the efficacy of propranolol in impairing fear memory reconsolidation is not limited to the age or strength of the memory.

نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۲/۹/۳ | پذیرش: ۱۳۹۲/۱۱/۱۵ | انتشار: ۱۳۹۳/۴/۱۰

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