دوره 5، شماره 1 - ( Winter 2014 -- 1392 )                   جلد 5 شماره 1 صفحات 42-47 | برگشت به فهرست نسخه ها


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Kaka G, Rahmanzade R, Safee F, Haghparast A. Naloxone Induces Frequent Jumping after Chronic Morphine and Methamphetamine Co-Administration in Rats. BCN. 2014; 5 (1) :42-47
URL: http://bcn.iums.ac.ir/article-1-467-fa.html
Naloxone Induces Frequent Jumping after Chronic Morphine and Methamphetamine Co-Administration in Rats. مجله علوم اعصاب پایه و بالینی. 1392; 5 (1) :42-47

URL: http://bcn.iums.ac.ir/article-1-467-fa.html


چکیده:  

Combined use of an opioid with a psychostimulant is popular among drug abusers. Such “polydrug use” may increase drug effects or attenuate adverse effects of either drug alone. We proposed that a combination of methamphetamine (meth) and morphine may change physical opioid withdrawal symptoms. Adult male rats were chronically injected with cumulative subcutaneous (s.c.) doses of morphine, meth or a combination of both drugs within five days. On day six, a challenge dose of the same drug was injected. Two hours later, precipitated withdrawal symptoms were scored within 30 minutes after naloxone (1mg/kg, i.p.) injection. Both frequency and incidence of jumping significantly increased in combined treated animals (P<0.05). The sole emergent symptom in combined treated animals was digging which we consider as another escaping behavior in addition to jumping. Our findings imply that combined use of meth and morphine may exacerbate averseness of morphine withdrawal which may cause more intense opioid dependence

نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۲/۵/۲ | پذیرش: ۱۳۹۲/۵/۳۰ | انتشار: ۱۳۹۲/۱۰/۱۱

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