دوره 4، شماره 3 - ( Summer 2013 -- 1392 )                   جلد 4 شماره 3 صفحات 224-231 | برگشت به فهرست نسخه ها



PMID: 25337351
PMCID: PMC4202567

Cited 1 time in PubMed Central

XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Keshvari F, Pouretemad H, Ekhtiari H. The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory. BCN. 2013; 4 (3) :224-231
URL: http://bcn.iums.ac.ir/article-1-406-fa.html
The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory. مجله علوم اعصاب پایه و بالینی. 1392; 4 (3) :224-231

URL: http://bcn.iums.ac.ir/article-1-406-fa.html


چکیده:  

Introduction: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whether bilateral modulation of the DLPFC using a noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modi.es the working memory function in healthy adults.

Methods: In a randomized sham-controlled cross-over study, 60 subjects (30 Males) received sham and active tDCS in two subgroups (anode left/cathode right and anode right/cathode left) of the DLPFC. Subjects were presented working memory n-back task while the reaction time and accuracy were recorded.

Results: A repeated measures, mixed design ANOVA indicated a signi.cant difference between the type of stimulation (sham vs. active) in anodal stimulation of the left DLPFC with cathodal stimulation of the right DLPFC [F(1,55)= 5.29,  P=0.019], but not the inverse polarity worsened accuracy in the 2-back working memory task. There were also no statistically signi.cant changes in speed of working memory [F(1,55)= 0.458 ,P=0.502] related to type or order of stimulation..

Discussion: The results would imply to a polarity dependence of bilateral tDCS of working memory. Left anodal/ right cathodal stimulation of DLPFC could impair working memory, while the reverser stimulation had no effect. Meaning that bilateral stimulation of DLFC would not be a useful procedure to improve working memory. Further studies are required to understand subtle effects of different tDCS stimulation/inhibition electrode positioning on the working memory.

نوع مطالعه: Original | موضوع مقاله: Cellular and molecular Neuroscience
دریافت: ۱۳۹۲/۵/۱۹ | پذیرش: ۱۳۹۲/۶/۱ | انتشار: ۱۳۹۲/۶/۱

کلیه حقوق این وب سایت متعلق به Basic and Clinical Neuroscience می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2015 All Rights Reserved | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb