دوره 5، شماره 2 - ( Spring 2014 1393 )                   جلد 5 شماره 2 صفحات 138-143 | برگشت به فهرست نسخه ها



PMID: 27545646
PMCID: PMC5071561

Cited 0 times in PubMed Central

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Rahimi Shourmasti F, Goudarzi I, Abrari K, Elahdadi Salmani M, Lashkarboluki T. Riluzole Ameliorates Harmaline-Induced Tremor in Rat. BCN. 2014; 5 (2) :138-143
URL: http://bcn.iums.ac.ir/article-1-345-fa.html
Riluzole Ameliorates Harmaline-Induced Tremor in Rat. مجله علوم اعصاب پایه و بالینی. 1393; 5 (2) :138-143

URL: http://bcn.iums.ac.ir/article-1-345-fa.html


چکیده:  

Introduction: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of current study was to investigate the effects of riluzole on harmaline-induced tremor in rat. Material and Methods: Four groups of Wistar rats weighing 80–100 g were injected with harmaline (30 mg/kg i.p.) for inducing experimental tremors. The rats in group 1 served as control, whereas the animals in groups 2, 3 and 4 were also given riluzole intraperitonealy at doses of 2, 4 and 8 mg/kg 30 min before and 90 min after harmaline administration. The onset latency, intensity and duration of tremor were recorded. Results: The results of this study demonstrated that riluzole could significantly increase latency period, and reduce duration and intensity of tremor. Discussion: It is concluding that pretreatment of riluzole can ameliorate harmaline-induced tremor in rats.

نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۱/۱۲/۷ | پذیرش: ۱۳۹۲/۴/۱۹ | انتشار: ۱۳۹۳/۱/۱۲

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