دوره 5، شماره 2 - ( Spring 2014 1393 )                   جلد 5 شماره 2 صفحات 131-137 | برگشت به فهرست نسخه ها


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maghsoudi N, ghasemi R, Ghaempanah Z, Motavalizadeh Ardekani A, nooshinfar E. Effect of Chronic Restraint Stress on HPA Axis Activity and Expression of BDNF and Trkb in the Hippocampus of Pregnant Rats: Possible Contribution in Depression during Pregnancy and Postpartum Period. BCN. 2014; 5 (2) :131-137
URL: http://bcn.iums.ac.ir/article-1-342-fa.html
Effect of Chronic Restraint Stress on HPA Axis Activity and Expression of BDNF and Trkb in the Hippocampus of Pregnant Rats: Possible Contribution in Depression during Pregnancy and Postpartum Period. مجله علوم اعصاب پایه و بالینی. 1393; 5 (2) :131-137

URL: http://bcn.iums.ac.ir/article-1-342-fa.html


چکیده:  
Introduction: Brain-Derived Neurotrophic Factor (BDNF) and its receptor, TrkB, in the hippocampus are targets for adverse effects of stress paradigms in addition, BDNF and its receptor play key role in the pathology of brain diseases like depression. In the present study, we evaluated the possible role of hippocampal BDNF in depression during pregnancy, Methods: To achieve the purpose, repeated restrain stress (1 or 3 hours daily for 7 days) during the last week of pregnancy was used and alteration in the gene expression of hippocampal BDNF and TrkB evaluated by semi-quantitative PCR. Results: The results showed that in stress group the level of ACTH and Corticosterone is increased showing that our model was efficient in inducing psychological stress we also found that BDNF and TrkB expression are decreased in 3 hours stress group but not in 1 hour stress compared to control group. Discussion: Our results imply that decrease in BDNF and its receptor could contribute in some adverse effects of stress during pregnancy such as elevation of depressive like behavior.
نوع مطالعه: Original | موضوع مقاله: Cellular and molecular Neuroscience
دریافت: ۱۳۹۱/۱۱/۲۸ | پذیرش: ۱۳۹۲/۱/۲۸ | انتشار: ۱۳۹۳/۱/۱۲

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