دوره 1، شماره 3 - ( Spring 2010 -- 1389 )                   جلد 1 شماره 3 صفحات 17-20 | برگشت به فهرست نسخه ها


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Mehdizadeh M, Katebi M, Soleimani M, Farahani Pad M H, Hoseini Tehrani A, Taghi Joghataei M. The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain. BCN. 2010; 1 (3) :17-20
URL: http://bcn.iums.ac.ir/article-1-33-fa.html
The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain. مجله علوم اعصاب پایه و بالینی. 1389; 1 (3) :17-20

URL: http://bcn.iums.ac.ir/article-1-33-fa.html


چکیده:  

A B S T R A C T

 Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators.

Results: Neuronal ultrastructure significantly improved in K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with control group.

 Discussion: Our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat.

نوع مطالعه: Original | موضوع مقاله: Cellular and molecular Neuroscience
دریافت: ۱۳۸۸/۱۱/۲۹

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