Volume 3, Issue 2 (Winter 2012 -- 2012)                   BCN 2012, 3(2): 12-15 | Back to browse issues page

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Alipanahzadeh H, Soleimani M, Soleimani Asl S, Mehdizadeh M. The Effect of TGF-alpha on Neurogenesis in Subventricular Zone of Rat Brain after Ischemia-Reperfusion. BCN. 2012; 3 (2) :12-15
URL: http://bcn.iums.ac.ir/article-1-208-en.html


Stroke is the third important reason of death in adults and an important cause of adult disability. Previous studies suggest that TGF-alpha can induce neurogenesis after stroke. Here in, we studied neurogenesis effects of the TGF-alpha on subventricular zone following ischemia-reperfusion. Male wistar rats (250-300 g) were divided into ischemia and treatment groups. After induction of ischemia-reperfusions, PBS (phosphate buffer salin) and TGF-alpha 50 ng were injected stereotaxicaly in lateral ventricle in ischemia and treatment respectively. After 12 days, the nestin expression in subventricular zone was assessed by immunohistochemical staining method.


Our results showed that nestin expression increased significantly in treatment group in comparison with ischemia group (p<0.05) .


Expression of nestin in SVZ indicates that TGF- α can stimulate the neural stem cells proliferation after ischemia –reperfusion injury.


Type of Study: Original | Subject: Clinical Neuroscience
Received: 2012/04/19

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