Volume 2, Issue 4 (Summer 2011 -- 2011)                   BCN 2011, 2(4): 53-57 | Back to browse issues page

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Shahidi S, Hashemi-Firouzi N, Mahmoodi M. Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze. BCN. 2011; 2 (4) :53-57
URL: http://bcn.iums.ac.ir/article-1-179-en.html

Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior in mice.


Male mice were intraperitoneally (i.p.) administrated sildenafil (1, 2, or 10 mg/kg), and the control group was given the vehicle 15 min before the plus-maze test. The number of entries into the open arms of the plus-maze, the time spent in the open arms, and the total numbers of entries into the arms were recorded.


The results indicated that compared to the control group, the sildenafil-treated mice spent more time in the open arms and had a greater number of entries into open arms. The total number of entries into the arms did not significantly differ between the sildenafil-treated groups and the control group.


Acute administration of sildenafil could have anxiolytic effects on male mice. This effect might be mediated in a time-dependent manner by the NO/ cGMP/PDE5 pathway.

Type of Study: Original | Subject: Clinical Neuroscience
Received: 2012/03/5

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