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Purpose: Synaptic plasticity has been suggested as the major physiological mechanism underlying memory formation. A lot of studies had been done to find whether the mechanisms involved in LTP, are run during learning. Nevertheless there are limited direct evidence that hippocampal-dependent learning actually triggers synaptic plasticity. In this study we investigated if learning and memory in Barnes maze test are accompanied with occurrence of LTP in Schaffer collateral to CA1 synapses in freely moving rats.
Methods: Animals were implanted with a recording electrode in stratum radiatum and stimulating electrodes in Schaffer collaterals of CA1 region in dorsal hippocampus of right hemisphere. Following the recovery period of at least 10 days, field potentials were recorded in freely moving animals before and after training the rats in Barnes maze as a hippocampal dependent spatial learning and memory test. Slope of evoked field excitatory post synaptic potentials (fEPSPs) were calculated before and after Barnes maze test.
Results: Obtained results show that fEPSP slope did not change after learning and memory in Barnes maze test and this spatial learning not resulted to change in synaptic potentiation in CA1 region of hippocampus.
Conclusion: Therefore, it may be concluded that spatial learning and memory in Barnes maze test are not accompanied with LTP induction in Schaffer collateral-CA1 synapses.
نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۷/۶/۱۱ | پذیرش: ۱۳۹۷/۷/۳

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