دوره 10، شماره 1 - ( January & February 1397 )                   جلد 10 شماره 1 صفحات 13-22 | برگشت به فهرست نسخه ها


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Nikkar E, Ghoshooni H, Hadipour M M, Sahraei H. Effect of Nitric Oxide on Basolateral Amygdala on Persistence of Anxiety and Depression in Stressed Male Rats. BCN. 2019; 10 (1) :13-22
URL: http://bcn.iums.ac.ir/article-1-1133-fa.html
Effect of Nitric Oxide on Basolateral Amygdala on Persistence of Anxiety and Depression in Stressed Male Rats. مجله علوم اعصاب پایه و بالینی. 1397; 10 (1) :13-22

URL: http://bcn.iums.ac.ir/article-1-1133-fa.html


چکیده:  
Introduction: The current study aimed at investigating the role of Nitric Oxide (NO) in the maintenance of anxiety and depression induced by stress in male Wistar rats using intra-Basolateral Amygdala (BLA) injection of NO precursor, L-arginine, Nitric Oxide Synthase (NOS) inhibitor, and L-NAME. 
Methods: Two 23-gauge stainless steel cannulas were placed in the BLA, stereotaxically. Seven days later, animals experienced electro foot shock stress based on the following protocol: animals experienced four sessions of stress for 60 minutes in four consecutive days. Five minutes before each stress session, the animals received different doses of L-arginine or L-NAME (1, 5 and, 10 μg/rat) or saline (0.5 μL/rat) intra-BLA. Six days after the stress termination, animals were tested for maintenance of anxiety-like behavior (elevated plus maze; EPM) and eight days after the stress they were examined for depression (forced swimming test; FST).
Results: Stress reduced the time and number of open arms and decreased motor activity on EPM. Stress-induced anxiety was inhibited by L-arginine and L-NAME (1, 5, and 10 µg/rat). L-Arginine and L-NAME induced anxiety in non-stressed rats. Stress also increased the immobility time in animals in FST paradigm. Interestingly, both L-arginine and L-NAME, in all doses reduced the stress effect.
Conclusion: BLA nitric oxide may play a pivotal role in anxiety and depression induced by stress in rats. Since the effects of both L-arginine and L-NAME were similar, NO might have a modulatory role in the BLA. 
نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۶/۱۱/۳۰ | پذیرش: ۱۳۹۷/۴/۲۶ | انتشار: ۱۳۹۷/۱۰/۱۱

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