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Many genetic studies are conducted for obsessive-compulsive disorder; however, there is not yet a throughout examination of proteome profile of this severe disorder. Here, the proteomic study of OCD patients’ serum samples is conducted by the application of two-dimensional electrophoresis (2DE) followed by Mass Spectrometry (MALDI-TOF-TOF).  A total of 240 protein spots were detected and among them, five significant differentially expressed protein spots with the fold change ≥ 1.5 were consider for further evaluations. These proteins include two isoforms of HP, IGKC, GC, and HPX. The first two shows down-regulation while the last ones indicate up-regulation. Moreover, a validation study of overall HP levels in patients’ serum via Nephelometric quantification confirmed the lower levels of this protein in the serum of OCD patients.  Additionally, enrichment analysis and validation test revealed that inflammation is one of most dominant processes in OCD. It is suggested that these candidate proteins and their underlying processes (especially, inflammation) may be linked to OCD pathophysiology and may have a  clinical utility after extensive validation studies. 
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2017/12/6 | Accepted: 2018/02/24 | Published: 2018/04/18

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