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Derafshpour L, Saboory E, Vafaei A A, Rashidy-Pour A, Roshan-Milani S, Rasmi Y, et al . Interactive effects of exercise, sex hormones, and transient congenital hypothyroidism on long-term potentiation in hippocampal slices of rat offspring. BCN. 2017;
URL: http://bcn.iums.ac.ir/article-1-1074-fa.html
Interactive effects of exercise, sex hormones, and transient congenital hypothyroidism on long-term potentiation in hippocampal slices of rat offspring. مجله علوم اعصاب پایه و بالینی. 1395;

URL: http://bcn.iums.ac.ir/article-1-1074-fa.html


چکیده:  
The long-term adverse effects of transient thyroid function abnormalities at birth on intellectual development have been proven to be improved. The effect of exercise increases in the presence of sex hormones. This study aimed to investigate the possibility that a combination of sex hormones and exercise has synergistic effects on neural plasticity in Transient congenital hypothyroidism (TCH) in rats. To induce hypothyroidism in the mothers, 6-propyl-2-thiouracil (PTU) was added to drinking water (100 mg/L) at the 6th day of gestation and continued until the 21st postnatal day (PND 21). From PND 28 to 47, the female and male pup rats received 5 μg/kg of 17β-estradiol and 0.5 mg/kg of testosterone, respectively. The mild treadmill exercise began 30 min after the sex hormones or vehicle administration. On PND 48, electrophysiological experiments were performed on brain slices. There was no significant difference in the LTP of sedentary-non-hormone male rats between control and TCH groups. But increase of LTP was observed in sedentary-non-hormone female rats of TCH group compared with the control. The exercise enhanced LTP in control rats but the hormones showed no significant effect. The effect of exercise and sex hormone was not significant in TCH group. The combination of exercise and testosterone (but none of them individually) enhanced LTP in TCH male rats, while the combination of exercise and estradiol or individually did not produce such an effect on LTP in TCH female rats.
The findings showed that despite the returning of thyroid hormone levels to normal range in TCH female rats an increase in excitatory transmission was observed. Also a combination treatment including exercise and testosterone (but not exercise or testosterone individually) enhanced LTP in male rats of TCH group, which is a sex-specific event.
 
نوع مطالعه: Original | موضوع مقاله: Behavioral Neuroscience
دریافت: ۱۳۹۶/۸/۲۲ | پذیرش: ۱۳۹۷/۲/۱۰ | انتشار: ۱۳۹۷/۲/۲۳

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