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Taslimi Z, Komaki A, Haghparast A, Sarihi A. Effects of Acute and Chronic Restraint Stress on Reinstatement of Extinguished Methamphetamine-Induced Conditioned Place Preference in Rats. BCN. 2017;
1- Ph.D. Student Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- PhD Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3- PhD Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Introduction: Methamphetamine (METH) is a neurotoxic psychostimulant with highly addictive potential and leads to compulsive drug use and vulnerability to relapse. Environmental cues, such as drug exposure, peer influence and social stress, are the powerful triggers of drug relapse. In  this  studywe  tried  to  find  out  the effect of acute and chronic restraint stress on reinstatement of extinguished METH-induced conditioned  place  preference  (CPP)  in  rats.
Methods: Subcutaneous (s.c.) administration of METH (0.125, 0.25, 0.5, 1, 2 and 4 mg/kg) could induce CPP which dose of 0.5 mg/kg was more potent than other doses. In  extinction phase,  rats  were  put  in  the  CPP  box  for  30  min  per  day  for  8 consecutive days.  After  extinctionanimals  were  exposed  to restraint stress (3-h period, as an acute stress) 60  min  before  subcutaneous  administration  of  ineffective  dose  of  METH  (0.125  mg/kg)  in  order  to  reinstate  the  extinguished  METH-induced CPP. For induction the chronic stress during extinction phase animal exposed the restraint stress for a 1-h period/day.
 Results: The results showed that the effective dose of METH to induce CPP was 0.5 mg/kg. 
Also result  revealed  that  physical  stress  (restraint stress) acute and chronic can  significantly  induce  reinstatement  of METH-induced CPP (P˂0.001) in extinguished animals.
Conclusion: Additionally, the chronic restraint stress could reduce
duration of extinction (maintenance) of METH-induced CPP. It is supposed that exposure the stress induce the relapse in abstinent amphetamine, but acute and chronic situation have a different reaction.
Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2017/10/11 | Accepted: 2017/11/15 | Published: 2017/11/16

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