Volume 8, Issue 5 (September & October 2017)                   BCN 2017, 8(5): 395-404 | Back to browse issues page




DOI: 10.18869/nirp.bcn.8.5.395

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Khodamoradi M, Asadi-Shekaari M, Esmaeili-Mahani S, Sharififar F, Sheibani V. Effects of Hydroalcoholic Extract of Soy on Learning, Memory and Synaptic Plasticity Deficits Induced by Seizure in Ovariectomized Rats . BCN. 2017; 8 (5) :395-404
URL: http://bcn.iums.ac.ir/article-1-825-en.html

1- Ph.D. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
2- Associate Professor Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
3- Associate Professor Department of Biology, Faculty of Science, Shahid Bahonar University, Kerman, Iran.
4- Professor Herbal and Traditional Medicines Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
5- PhD Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Abstract:  

Introduction: Previous studies have shown that seizure can induce cognitive impairment. On the other hand, soy phytoestrogens, which are mainly found in soybean (Glycine max (L.) Merr.), have beneficial effects on the nervous system. However, little is known about their probable effects on seizure. The present study aimed to examine the probable effects of soy extract, containing the phytoestrogen genistein on seizure-induced cognitive and synaptic plasticity impairment in Ovariectomized (OVX) rats.
Methods: Rats were ovariectomized, implanted with guide cannula and then divided into 5 groups (n=7-8 in each group): PBS, KA, Saline-KA, Higher Dose Soy (HDS-KA), and Lower Dose Soy (LDS-KA) groups. Animals of the HDS-KA and LDS-KA groups received intraperitoneal administration of soy extract (20 and 2 mg/kg, respectively) and the Saline-KA group received normal saline once a day for 4 days. Sixty minutes after the last injection, Kainic Acid (KA) or PBS was injected into the left lateral ventricle via pre-implanted guide cannula to induce generalized seizures. The Morris water maze task and in vivo field potential recordings were conducted 7 days later.
Results: Soy extract at both doses significantly improved learning impairment and at the higher dose (20 mg/kg) significantly prevented seizure-induced spatial memory impairment and deficit of long-term potentiation in the hippocampus.
Conclusion: The soy extract containing the phytoestrogen genistein may have beneficial effects on memory deficit induced by seizure in OVX rats and this effect is accompanied by a beneficial effect on synaptic plasticity.

Type of Study: Original | Subject: Behavioral Neuroscience
Received: 2016/09/6 | Accepted: 2016/09/24 | Published: 2017/09/19

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