Volume 2, Issue 1 (Autumn2010 -- 2010)                   BCN 2010, 2(1): 20-23 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Baluchnejadmojarad T, Roghani M. The Flavonoid Hesperetin Alleviates Behavioral Abnormality in 6-Hydroxydopamine Rat Model of Hemi-Parkinsonism. BCN 2010; 2 (1) :20-23
URL: http://bcn.iums.ac.ir/article-1-63-en.html
Abstract:  

ABSTRACT

Parkinson’s disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the administration of this flavonoid would attenuate behavioral abnormalities in an experimental model of PD in rat. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA, 12.5 μg/5μl of saline-ascorbate)-lesioned rats were pretreated i.p. with hesperetin (10 mg/kg). It was found out that hesperetin administration attenuates the rotational behavior in lesioned rats. In summary, hesperetin administration attenuates behavioral abnormality in hemiparkinsonian rats and this may be of benefit, along with other therapies, in neurodegenerative disorders including PD.

Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2011/03/22 | Published: 2010/11/15

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Basic and Clinical Neuroscience

Designed & Developed by : Yektaweb