Volume 3, Issue 2 (Winter 2012 -- 2012)                   BCN 2012, 3(2): 56-59 | Back to browse issues page

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Kamali Ardekani S, Khoshnevisan A, Shahbazi A. Distribution of Age and Location of Chordoma in 39 Cases and Review of Treatment Options. BCN. 2012; 3 (2) :56-59
URL: http://bcn.iums.ac.ir/article-1-213-en.html


notochord. Although histologically benign, these tumors are locally aggressive

and present significant managment challenges . There arew some studies on

evaluated the location, age and gender of the patients with Chordoma in two

referral centers in Tehran.

chordoma cases but there was no study about Iranian cases. In this study we
Skull base chordomas are rare neoplasms arising from the


(Shariati and Imam Hospitals, Tehran) from 2001 to 2011 was retrospectively


A database of patients with chordoma tumors referred to two centers


women, and they are most commonly diagnosed in middle-aged (mean age was

50.6). Tumors typically occur in the axial skeleton and have a tendency for the

spheno-occipital region of the skull base and sacral region. In adults 33.3% of

chordomas involve the sacrococcygeal region, 53% occured at the base of the

skull near the spheno-occipital area, and near 14% were found in the vertebral

column. The cranial nerves mostly affected were abducens, oculomotor and

trochlear, with some overlaps. All patients were treated with surgery and some

cases referred for gamma-knife radiosurgery (GKS).

In our subjects tumors affect men nearly twice as frequently as


to females that is different from other studies, however, few studies reported

more male to female ratio. Despite the progress in current surgical techniques

and some encouraging results with the use of targeted therapy, disease control

and long-term prognosis of patients are still poor.

Findings of this study showed more involvement of males compare
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2012/04/19 | Published: 2012/02/15

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