Volume 2, Issue 4 (Summer 2011 -- 2011)                   BCN 2011, 2(4): 5-11 | Back to browse issues page

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Niehues da Cruz J, Delwing de Lima D, Delwing Dal Magro D, Geraldo Pereira da Cruz J. The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin. BCN 2011; 2 (4) :5-11
URL: http://bcn.iums.ac.ir/article-1-173-en.html
The Power of Classic Music to Reduce Anxiety in Rats Treated with Simvastatin
Júlia Niehues da Cruz1 , Daniela Delwing de Lima2 , Débora Delwing Dal Magro3 , José Geraldo Pereira da Cruz * 4
1- Universidade do Extremo Sul Catarinense, Santa Catarina, Brazil
2- Universidade da Região de Joinville, Santa Catarina, Brazil
3- Universidade Regional de Blumenau, Santa Catarina, Brazil
4- Department of Natural Sciences, Universidade Regional de Blumenau, Santa Catarina, Brazil
Abstract:  

Introduction: This study was designed to investigate the effects of music in Wistar rats after sub-chronic treatment of simvastatin. The rats were orally administered with either simvastatin or saline (controls). After 4 weeks of drug treatment, the rats were selected for behavioral studies. The rats were exposed to music 24 hours before behavioral tests (Mozart’s piano sonata, KV361, Largo).

Results:

The experiments suggest that exposure to chronic treatment with simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in rats when associated with Mozart music in an elevated plus-maze.

Discussion:

These results indicate that music can serve as an effective adjuvant in rats treated with simvastatin, and that this species could potentially be used in other preclinical models utilizing musical interventions.

Methods:

Keywords: Music, Elevated plus-maze, Open-field, Rattus norvegicus, Simvastatin.
Full-Text [PDF 724 kb]      
Type of Study: Original | Subject: Clinical Neuroscience
Received: 2012/03/5 | Published: 2011/08/15
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