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URL: http://bcn.iums.ac.ir/article-1-33-en.html
1, Majid Katebi2 , Mansoure Soleimani1 , Mohammad Hassan Farahani Pad3 , Ali Hoseini Tehrani3 , Mohammad Taghi Joghataei1
2- Department of Anatomy, School of Medicine, Hormozgan University of Medical Sciences
3- School of Medicine, Azad University
A B S T R A C T
Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators.
Results: Neuronal ultrastructure significantly improved in K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with control group.
Discussion: Our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat.
Received: 2010/02/18 | Published: 2010/05/15
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