Volume 1, Issue 3 (Spring 2010 -- 2010)                   BCN 2010, 1(3): 17-20 | Back to browse issues page


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Mehdizadeh M, Katebi M, Soleimani M, Farahani Pad M H, Hoseini Tehrani A, Taghi Joghataei M. The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain. BCN. 2010; 1 (3) :17-20
URL: http://bcn.iums.ac.ir/article-1-33-en.html

1- Department of Anatomy, School of Medicine, Iran University of Medical Sciences
2- Department of Anatomy, School of Medicine, Hormozgan University of Medical Sciences
3- School of Medicine, Azad University
Abstract:  

A B S T R A C T

 Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators.

Results: Neuronal ultrastructure significantly improved in K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with control group.

 Discussion: Our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat.

Type of Study: Original | Subject: Cellular and molecular Neuroscience
Received: 2010/02/18

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